What settings are the best?

There is no "best strategy" for automated cryptocurrency trading, it is not a money making machine. 

You may use one of the templates to start and adjust them according to your needs after.

To get the best results you should conduct your own research and make your strategy, according to your trading volume, market situation, chosen cryptocurrency pair and etc. 

First of all, you may check out bot's available features and functions. So, find out the way it works:

https://tradesanta.com/en/how-it-works

We also have video tutorials:

https://tradesanta.com/en/video-tutorials

TradeSanta on Youtube.